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Total 12445 results found since Jan 2013.

Cone-Beam CT: Vascular Applications
Cone-beam computed tomography (CBCT) provides three-dimensional rendering of opacified vascular structures that are very useful for catheter guidance and anatomical correlation in many arterial and venous procedures. CBCT has been shown to improve the technical success of transarterial chemoembolization (TACE), which may lead to better outcomes. Similarly, it is useful in planning for selective internal radiation therapy of the liver by defining the treatment volume and preventing misembolization. There is emerging application of CBCT fusion with magnetic resonance angiography (MRA) or computed tomographic angiography (CTA...
Source: Techniques in Vascular and Interventional Radiology - August 31, 2013 Category: Radiology Authors: John F. Angle Source Type: research

Vascular interventions in head and neck cancer patients as a marker of poor survival
Head and neck cancer can involve the surrounding vasculature and require technically challenging vascular interventions. These interventions can be complicated by tumor invasion, history of prior surgery, and history of radiation therapy. Our aim was to examine patients with vascular interventions in association with head and neck cancer to determine outcomes and best practice.
Source: Journal of Vascular Surgery - December 19, 2018 Category: Surgery Authors: Emilia Krol, Colin T. Brandt, Juliet Blakeslee-Carter, Sadie S. Ahanchi, David J. Dexter, Daniel Karakla, Jean M. Panneton Tags: Clinical research study Source Type: research

Investigational therapies for Ewing's sarcoma: a search without a clear finding.
Authors: Vornicova O, Bar-Sela G Abstract INTRODUCTION: Ewing sarcoma family tumors (ESFT) are a group of aggressive diseases, characterized histologically by small, round, blue cells and genetically by translocation involving EWS and ETS partner genes. The current treatment of localized Ewing sarcoma (ES) requires a multi-disciplinary approach, including multidrug chemotherapy, administrated before and after local treatment, surgery and radiation therapy. Unfortunately, the cure rate of metastatic or refractory/recurrent disease is still very poor. Areas covered: In this review, the authors summarize the new types...
Source: Expert Opinion on Investigational Drugs - March 20, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

< em > TFEB < /em > -translocated and -amplified renal cell carcinoma with < em > VEGFA < /em > co-amplification: A case of long-term control by multimodal therapy including a vascular endothelial growth factor-receptor inhibitor
CONCLUSION: A good long-term response to anti-vascular endothelial growth factor drug therapy may be due to VEGFA amplification and subsequent vascular endothelial growth factor overexpression.PMID:37144078 | PMC:PMC10151203 | DOI:10.1002/iju5.12575
Source: Cancer Control - May 5, 2023 Category: Cancer & Oncology Authors: Hajime Takamori Akiko Miyagi Maeshima Ikuma Kato Masaya Baba Eijiro Nakamura Yoshiyuki Matsui Source Type: research

YAP1/TAZ activity maintains vascular integrity and organismal survival
Biochem Biophys Res Commun. 2022 Jun 19;619:117-123. doi: 10.1016/j.bbrc.2022.06.050. Online ahead of print.ABSTRACTRadiation therapy is one of the major treatment modalities for patients with cancers. However, ionizing radiation (IR) damages not only cancer cells but also the surrounding vascular endothelial cells (ECs). Hippo pathway effector genes Yap1 and Taz are the two transcriptional coactivators that have crucial roles in tissue homeostasis and vascular integrity in various organs. However, their function in adult ECs at the steady state and after IR is poorly understood. Here, we report sex- and context-dependent ...
Source: Cell Research - June 26, 2022 Category: Cytology Authors: Shun Uemura Masayuki Yamashita Kazumasa Aoyama Takako Yokomizo-Nakano Motohiko Oshima Miki Nishio Masayoshi Masuko Jun Takizawa Hirohito Sone Yasuhiro Yamada Akira Suzuki Atsushi Iwama Source Type: research

Percutaneous fractionated radiotherapy of the groin to eliminate lymphatic fistulas after vascular surgery
CONCLUSION: Low-dose irradiation of the groin is a treatment option for persistent lymphatic fistula after inguinal vascular surgery.PMID:36755343 | DOI:10.1186/s40001-023-01033-6
Source: Cell Research - February 9, 2023 Category: Cytology Authors: Danny Jazmati B álint Tamaskovics Norman-Philipp Hoff Bernhard Homey Edwin B ölke Belebenie Boyomo Waseem Garabet Jan Haussmann Wilfried Budach Judith Neuwahl Hubert Schelzig Stefanie Corradini Martijn van Griensven Johannes Fischer Wolfram Trudo Knoefe Source Type: research

Mitochondrial Ca < sup > 2+ < /sup > Uptake Drives Endothelial Injury By Radiation Therapy
CONCLUSIONS: Irradiation-induced damage to mtDNA is driven by MCU-dependent Ca2+ influx and the generation of mtROS. Such damage leads to reduced transcription of mitochondrial genes and activity of the ETC, promoting sustained mtROS production that induces endothelial dysfunction. Our findings suggest that targeting MCU and mtROS might be sufficient to mitigate irradiation-induced vascular disease.PMID:35899616 | DOI:10.1161/ATVBAHA.122.317869
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 28, 2022 Category: Cardiology Authors: Karima Ait-Aissa Olha M Koval Nathanial R Lindsey Isabella M Grumbach Source Type: research

Pancreatic Cancer with Vascular Involvement: Adherence to Current Standard-of-Care Associated with Improved Survival
CONCLUSIONS: Most resected pancreatic cancer patients in this study with vascular involvement receive either postoperative or no adjuvant therapy. N-MAC increases downstaging, R0 resection rates, and survival.PMID:36854081 | DOI:10.1177/00031348231156756
Source: The American Surgeon - February 28, 2023 Category: Surgery Authors: Abdimajid Mohamed Laura Nicolais Timothy L Fitzgerald Source Type: research

Does Vascular Collapse Occur after Treatment of Hepatocellular Cancer with Stereotactic Body Radiation Therapy?
Int J Radiat Oncol Biol Phys. 2023 Jul 4:S0360-3016(23)02195-8. doi: 10.1016/j.ijrobp.2023.06.078. Online ahead of print.ABSTRACTThere is debate about why stereotactic body radiation therapy (SBRT) produces superior control of hepatocellular cancer (HCC) compared to fractionated treatment. Both preclinical and clinical evidence has been presented to support a "classic" biological explanation: the greater BED of SBRT produces more DNA damage and tumor cell kill. More recently, preclinical evidence has supported the concept of a "new biology", particularly radiation-induced vascular collapse, which increases hypoxia and free...
Source: Physics in Medicine and Biology - July 6, 2023 Category: Physics Authors: Theodore S Lawrence Madhava Aryal Joseph Evans Kyle Cuneo Daniel Chang Matthew Schipper Yuhang Zhang James Balter Randy Ten Haken Yue Cao Source Type: research